Avasopasem manganese is a potent superoxide dismutase mimetic | MedChemExpress (MCE)-产品咨询-资讯-生物在线

Avasopasem manganese is a potent superoxide dismutase mimetic | MedChemExpress (MCE)

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Avasopasem manganese

MCE:Avasopasem manganese

Brand:MedChemExpress (MCE)

Cat. No:HY-109110

CAS:435327-40-5

Synonyms:GC-4419; M-40419

Purity0.9602

Storage:

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Shipping:Room temperature in continental US; may vary elsewhere.

Description:Avasopasem manganese (GC4419; M-40419) is a potent superoxide dismutase mimetic that rapidly and specifically converts O2*- to hydrogen peroxide (H2O2), arresting the initiation of this cascade. Avasopasem manganese can be used for the research of severe oral mucositis (SOM) and cancer[1].

In Vivo:

Avasopasem manganese is an agent intended to interrupt severe oral mucositis pathogenesis, to reduce the duration, incidence, and severity of radiation-induced oral mucositis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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References:

[1]. Anderson CM, et al. Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer [published correction appears in J Clin Oncol. 2020 Jan 20;38(3):288]. J Clin Oncol. 2019;37(34):3256-3265.

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