抗人IL1R2 / IL1RB CD121b鼠单抗
产品名称： 抗人IL1R2 / IL1RB CD121b鼠单抗
英文名称： IL1R2 / IL1RB / CD121b Antibody
产品编号： 10111-MM09
产品价格： null
产品产地： 北京
品牌商标： 义翘神州(SinoBiologi
更新时间： null
使用范围： WB
- 联系人 :
- 地址 : 北京亦庄东区科创十街18号院9号楼306室
- 邮编 : 100176
- 所在区域 : 北京
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- 传真 : 点击查看
- 邮箱 : marketing@sinobiological.cn
官方网址：http://www.sinobiological.cn/IL-1R2-CD121b-Antibody-g-5265.html
IL1R2 / IL1RB / CD121b Antibody
 | Order or Inquire for IL1R2 Antibody product |  | |
| Detection limit is 2 ng/lane in WB |
IL1R2 / IL1RB / CD121b抗体产品信息
| 免疫原 : | Recombinant human IL1R2 protein ( Catalog#10111-H08H ) |
| Antibody Type : | Mouse Monoclonal Antibody ( Mouse mAb Service Platform ) |
| 克隆号 : | 1H5D7D1 |
| 抗体宿主 : | Mouse IgG1 |
| 缓冲液 : | 0.2 μm filtered solution in PBS with 5% trehalose |
| 制备方法 : | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human IL1R2 ( rh IL1R2 ; Catalog#10111-H08H ; NP_004624.1 ; Met 1 - Glu 343 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
IL1R2 / IL1RB / CD121b Antibody Usage Guide
| 特异性 : | Human IL1R2 / IL1RB / CD121b |
| No cross-reactivity in WB and ELISA with Human IL1RA / IL1F3 Human IL1R1 / CD121a Human IL1R3 / IL1RAP Human IL1RL1 / IL1R4 / ST2 Human IL1RAPL1 / IL1R8 Human IL1R9 / IL1RAPL2 Human IL18R1 / CD218a Human cell lysate (293 cell line)
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| Western blot : | This antibody can be used at 1 - 2 μg/mL with the appropriate secondary reagents to detect human IL1R2 in WB. Using a DAB detection system, the detection limit for human IL1R2 is approximately 2 ng/lane under non-reducing conditions and 8 ng/lane under reducing conditions |
| 储存方法 : | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. |
IL1R2 / IL1RB / CD121b Antibody Related Products & Topics
相关领域:
Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-1R2/ CD121b
Immunology>>Cytokine & Receptor>>Interleukin & Receptor >>IL-1 Superfamily and IL-1R/TLR Family>>IL-1R2/ CD121b
Immunology>>Cluster of Differentiation>>B Cell CD Antigen>> IL-1R2/CD121b
Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers / Monocyte Markers>>IL-1R2/CD121b
Proteins:
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat No |
| IL-1R2/CD121b | Human | IL-1R2/CD121b/Fc Protein, Recombinant | 10111-H02H |
| IL-1R2/CD121b | Human | IL-1R2/CD121b Protein, Recombinant | 10111-H08H |
Antibodies:
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat No |
| Human IL-1R2/CD121b | WB | IL-1R2/CD121b Antibody, Mouse Mab | 10111-MM09 |
| Human IL-1R2/CD121b | WB, ELISA | IL-1R2/CD121b Antibody, Rabbit MAb | 10111-R020 |
| Human IL-1R2/CD121b | WB, ELISA | IL-1R2/CD121b Antibody, Rabbit PAb | 10111-RP01 |
| Human IL-1R2/CD121b | WB, ELISA | IL-1R2/CD121b Antibody, Rabbit PAb (Antigen Affinity Purified) | 10111-RP02 |
IL1R2 / IL1RB / CD121b 抗体背景综述
The pleiotropic cytokine IL1 is produced to regulate development and maintenance of the inflammatory responses, and binds to specific plasma membrane receptors on cells. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). A closely related receptor-like chain IL1R accessory protein (IL1RAcP) has been reported to heterodimerize with the IL1RI to form the signal transduction complex which appears to mediate all the known IL1 signal processes. IL1RII structurally consisting of a ligand binding portion comprised of three Ig -like domains, a single transmembrane region, and a short cytoplasmic domain, is expressed in a variety of cell types including B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Like the IL1RI, the human IL1RII can bind all three forms of IL1 (IL1 alpha, IL1 beta and IL1ra) but does not transmit IL1 signals. In addition to the membrane-bound form, IL1RII also exists as the soluble form, and either acts as a decoy receptor that inhibits IL1 action by blocking the binding of IL1 to the type I receptor complex. Furthermore, IL4 is reported to antagonize the activity of IL1 by inducing the expression and release of this cytokine. Recombinant soluble IL1RII is thus a potent antagonist of IL1 action, and serves as a potential therapeutic target.
参考文献
- McMahan, C.J. et al., 1991, EMBO J. 10: 2821-32.
- Liu, C. et al., 1996, J. Biol. Chem. 271: 20965-72.
- Rauschmayr, T. et al., 1997, Proc. Natl. Acad. Sci. USA. 94: 5814-19.
- Neumann, D. et al., 2000, J. Immunol. 165: 3350-7.
- Colotta, F. et al., 1993, Science. 261: 472-5.