分子量:69.3 kDa

纯度:>95% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Rhesus macaque DDR2, Fc Tag by the LAL method.

Buffer:50 mM tris, 100 mM glycine, pH7.5

生物活性:

产品特性:Rhesus macaque DDR2, Fc Tag is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 69.3 kDa. The predicted N-terminus is Lys 22. The reducing (R) protein migrates as 80-95 kDa in SDS-PAGE  due to glycosylation.

产品背景:Discoidin domain-containing receptor 2 (DDR2) is also known as CD167 antigen-like family member B (CD167b), Discoidin domain-containing receptor tyrosine kinase 2, Neurotrophic tyrosine kinase, receptor-related 3(NTRKR3),  Tyrosine-protein kinase TYRO10, Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. DDR2 is required for normal bone development. DDR2 regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. DDR2 regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. DDR2 promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.